WellAI: Intelligent Diagnostics for Better Outcomes

Medical Diagnostic/Digital Health Assistant/Engine for Patients/Physicians


In 2020, a group of internationally recognized data scientists developed a COVID-19 research tool (Source: https://www.prnewswire.com/news-releases/wellai-develops-covid-19-research-tool-in-response-to-white-houses-call-to-action-301036993.html). The tool incorporated four neural networks that read and assimilated over 45,000 publicly available medical studies focused on COVID-19 and evaluated relationships between hundreds of thousands of medical concepts. Researchers enter any set of concepts they are interested in and WellAI generates a list of medically relevant concepts. The researcher selects and narrows down the particular concept to delve further into. The International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) conducted a peer-reviewed study of WellAI’s COVID-19 tool and published the results: https://pubmed.ncbi.nlm.nih.gov/32549878/.

WellAI was created with a vision to eliminate the immense asymmetry of medical knowledge between participants in the healthcare industry, with the focus on doctors, nurses, and patients. Customers know almost everything about the car they are about to buy. But they don’t know much about what is happening and, more importantly, what could happen to their health.

Knowledge saves time and saves lives. With initial successes in primary care and urgent care, the WellAI platform is expanding its applications to dermatology, pediatrics, chronic care management and home care and has already proven to help patients with certain types of cancer.

WellAI for Medical Providers: Digital Front Door Solution

WellAI for Medical Providers enables medical practices/clinics to drive efficiency in light of staffing issues, create priority targeted health communication, and enable higher quality care. WellAI resolves issues related to the increased need for at-home care, overwhelmed front desks, and with thorough diagnostics ensures nurses never skip a critical question and presents physicians with alternative ways to think about a patient's condition.

The Solution

WellAI’s turnkey platform consists of a Patient Application and Physician Application that can run on any device or is browser-based. It includes configurable features such as:

  1. Triage/Diagnostic solution: More than 500 health conditions are diagnosed with 83%+ accuracy including common and pediatric conditions, rare disease and current conditions like COVID-19.
  2. Bi-Directional Messaging: Text/messaging with the nurse, physician(s), or care team. A diagnostic report can be sent to the practitioner instantly for discussion/diagnosis.
  3. Telehealth scheduling and connectivity: With a button push the patient is connected to a telehealth service or one is initiated - the diagnostic report kicks off a more intelligently engaged session.
  4. Appointment Scheduler: Patients connect to the scheduling system and have automated scheduling ability
  5. News/Informational Feed: Newsfeed of relevant health and clinic/facility information for the patient.
  6. Automated Medical Transcription: Automated compiling of patient notes where post-diagnosis treatment options are suggested with the doctors concluding notes input. The entire visit info is compiled into a PDF and attached or written to the EHR system.
  7. Autocall for Prescription Refills: With a click of a button the pharmacy will be contacted and refills
  8. Other Services: Customizable to accommodate what medical practitioners and their patients need.

All of this functionality is packaged in one point/click intuitive Patient/Physician application, plus it is customizable and is white-labeled for the organization. It integrates with many EMR systems (EPIC, Cerner, NextGen, etc), for some functions it will read-write to the system.

WellAI for Doctors - Digital Front Door Demo

Patients can fill out documents digitally through the app and it is a HIPAA compliant platform

WellAI Corporate and Digital Triage Health Assistant

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WellAI’s Triage/Diagnostic Digital Health Assistant

The same scientific team realized that they could expand the tool using the same technology in an evolutionary fashion to address a broader spectrum of health conditions. Towards Data Science published an article “3 AI Trends in Healthcare” (source: https://towardsdatascience.com/3-ai-trendsthat-will-revolutionise-healthcare-da4198dbb31d) focusing on the growing presentment of AI in three major areas: EHR, diagnostics, and telemedicine. The growing demand for more precise and intelligent analysis of ever-expanding datasets is evident in these areas. The challenge is that many tools lack the scientific capability to analyze these datasets effectively - going beyond decision trees and chatbots.

The WellAI team, breaking traditional AI boundaries, expanded the baseline tool with four additional neural networks enabling assimilation of over 30 million peer-reviewed medical articles, journals, case studies, and continuing to assimilate new publications as they emerged. This created a multidisciplinary diagnostic solution that addresses practically every known health condition from the common cold to rare diseases. The tool enables physicians and patients to, in a Siri-like fashion, simply speak their condition (how they are feeling). WellAI ‘listens’ and cuts through the white noise of emotion and non-essential context to derive and translate the medical symptoms into a diagnosis. Based on an initial set of symptoms, it will ask logically derived questions to medically clarify how the patient is feeling (much like a medical practitioner conducts patient intake) and arrive rapidly (in less than 2 minutes) at an initial diagnosis. WellAI limits the diagnostic outcome to one or two of most probabilistic health outcomes. WellAI provides a logical and scientifically validated starting point (or a scientific second opinion) for a physician or medical practitioner to begin the process of diagnostic validation and to create a prescriptive treatment plan.

The WellAI solution is presented in two forms. A Digital Health Assistant is an “app” downloaded onto a smartphone, computer, or iPad which a physician, patient, or caregiver can tap open and use anywhere, anytime or as an engine. The engine is essentially the neural net/AI technology which can be repurposed or used on the backend to power or enhance another solution (i.e. a front office workflow screening or EHR enhancement).

The Problem with Symptom Checkers and Clinical Diagnostic Tools

Starting in the late nineties, the emergence of online symptom checkers like WebMD began. Today there are numerous publicly available and easily accessed symptom checkers. According to a peer-reviewed study focusing on the efficacy of online symptom checkers, the performance was exceptionally poor. The researchers found not only diagnostic inaccuracy, but also a variability of performance execution. In fact, the performance was found to be significantly below what is accepted within the medical field. (Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0254088). Another study conducted by Ada Health using 200 vignettes (medical scenarios) offered a similar conclusion. While still advocated as a supplement to diagnostic validation, it is with great caution and concern that these online symptom checkers be used for health validation. A comparison of performance between WellAI and some known symptom checkers/competitive tools is below.

A number of clinical diagnostic solutions incorporating AI have emerged. Recently, tools like RecoverX, Artrya’s Salix, Ezra and a host of other solutions have emerged on the market accompanied by large funding rounds and/or great publicity (Source: https://www.mobihealthnews.com/tag/ai-diagnostic-tool). The key difference between these diagnostic solutions and WellAI is that they are extremely focused on one particular area. With the exception of RecoverX, which is essentially an AI interface for another solution, these tools are specialist tools with limited scope, application, and focus. While the performance is excellent, they are generally not designed for general use or public consumption.

The Accuracy Validation for WellAI

Notably for determining performance validation for symptom checkers, only 28 to 200 vignettes were used. A smaller sample encompasses more typical health scenarios and hence develops statistical biases and creates misleading results.

To validate the accuracy and performance of WellAI, more than 2400 vignettes spanning around 500 known diseases were identified and utilized. WellAI’s accuracy estimate is based on an internal study of 2,400 vignettes (400 actual + 2,000 resampled). All other estimates are from a recent study of 200 vignettes called “How accurate are digital symptom assessment apps for suggesting conditions and urgency advice? A clinical vignettes comparison to GPs”, Gilbert S, et al. BMJ Open 2020;10:e040269. doi:10.1136/bmjopen-2020-040269. Additionally, an independent board of physicians were enjoined to prove out WellAI’s accuracy, upon conclusion of the study - a 60% accuracy rate for the Top-1 Diagnosis was determined which increased to 85% or more with the layering of physician expertise. WellAI includes all 69 NIH medical disciplines (also known as 69 NIH’s UMLS semantic types) in its analytics.

Improved Speed and Accuracy of Diagnosis

In applying Bayes Theorem to Digital Health, specifically to a tool like WellAI - statistically speaking, the greater the amount of information, cross-correlated, and the better the ability to separate the quality from the statistical noise, the more accurate the outcome. Source: https://medium.com/@WellAI/bayes-theorem-for-digital-health-or-how-to-fight-misdiagnosis-with-statistics-29ad6f6229c1

  • 1. WellAI’s solution used alone by a patient or caregiver will generate an average of 60% accuracy for the Top-1 Diagnosis, or 83% accuracy for the Top-3 Diagnoses.
  • 2. Pairing WellAI’s solution with a physician or medical practitioner will yield the greater accuracy rate of 85% to 99%.

The Pain Points WellAI Addresses:

  1. Fast, accurate diagnosis (differential diagnosis) and diagnostic validation of medical conditions.
  2. Directs appropriate action and outcome based on the diagnosis
  3. Provides appropriate medical levels of care to children/elderly from caregivers
  4. Handles triage and patient intake in a faster, well documented, targeted and actionable fashion
Picture this:
  • 2:30 a.m. A founder’s pre-teen daughter wakes up feeling odd. An unusual lump is prominent on her neck that had not been there before. She is generally in good health, except for the lump and odd feeling. He and his wife are puzzled - what to do? ER? Doctor? Is it a gland that is swollen? An allergic reaction to nuts which she had? He used WellAI to quickly diagnose what it was (WellAI uniquely asked if she had a dentist visit - not a common question) - a tooth infection that spread and waited to take her to the doctor, avoiding an expensive and unnecessary ER visit.
  • A 49-year female WellAI user (since February 2021) shared her beautiful story of using the WellAI app. She is not a smoker. She has no preexisting or chronic condition. She has no known family history of cancer. She exercises and eats right. That’s why she was surprised when she started feeling certain symptoms that wouldn’t go away. She checked with the WellAI app and turned out she had anemia as the single highest probable diagnosis, according to WellAI. (Other leading symptom checkers on the market missed this diagnosis completely.) She still decided to go to a doctor, just in case. The doctor neither confirmed, nor denied the anemia diagnosis, and suggested additional tests. After two weeks of medical tests, it was confirmed it was indeed anemia, and in fact, anemia caused an early stage of myeloma cancer. She had to go through chemotherapy and did a stem cell transplant. But because WellAI caught cancer early, the treatment was not as intense, and she is now cancer-free!
  • A WellAI user reported that for a long time he could not get the right diagnosis for his rare back condition, spondylolisthesis. It took going to different doctors for several months to finally get to the bottom of his health problem. WellAI gave the right diagnosis in 50 seconds. Here is a quote from his testimony: “It did an excellent job of diagnosing a non-trivial back surgery I had many years ago--spondylolisthesis. I didn’t think it would get it. Very impressed on that one.”
With WellAI, in less than one minute, those critical questions of “What medical condition is it?” or “How serious is it?” are answered. Plus the tool provides appropriate direction to the right outcome – ER, doctor or something else.

The WellAI Engine

An analytical AI, multi-neural net driven application that has assimilated and processed more than 30 million medical studies, research articles, case studies, journals and continues to ‘learn’ and assimilate new information daily. The algorithms understand and sort medical concepts in order of relevance to other medical concepts. It has resolved the dimensionality problem in machine learning by assigning medical concepts to clusters (factors). The application addresses common ailments, rare diseases, COVID-19, advanced genomics, and, more recently, dermatology and pediatrics. It can accurately diagnose 500 medical conditions ranging from rare conditions to common health ailments.

The Engine is fundamentally a smartphone or computer application that uses a soothing, Siri-type voice to listen, comprehend symptoms and health status. Acting much like “Shaun - The Good Doctor” it will ‘swipe in and out’ of relevant medical information and ask continuing detailed diagnostic questions until it comes to a diagnosis.

The Cases for WellAI

WellAI clearly offers the broadest and most accurate human health diagnostic tool available with the greatest potential
  • Patient/Caregiver Diagnostic Tool: (Commercially available) A Smartphone or computer application that a patient or caregiver (child/elderly) can easily use 24/7 to diagnose or validate a medical condition. Recommends physician or ER visit based on severity of the diagnosis.
  • Physician Diagnostic Validation Tool: Similar to the Caregiver Tool it offers more in-depth research support and identifies patient conditions and may present alternatives to consider and be used for differential diagnosis (i.e. COVID-19, pneumonia, or bronchitis).
  • Triage Engine for Patient Portal/Screening: The WellAI engine was used by a busy physician practice as part of a self-service portal to add screening and priority scheduling capability. Patients talk to WellAI and based on the outcome would connect to priority scheduling, a physician (if critical issue), or to informational resources and general scheduling. WellAI reduced non-essential calls and escalated essential calls with greater effectiveness.
  • Telemedicine Enhancement: WellAI is used as the first step diagnostic solution to eliminate time-consuming intake. It creates a report for the telemedicine practitioner who then immediately begins validation and treatment.
  • Medical Concept Cloud/Transcription: WellAI can interface with EMR solutions extracting the patient’s information and presenting symptoms/medical diagnosis in a concept cloud and it can be used similarly with respect to transcription, plus assigns ICD-10 codes to the diagnosis for accurate billing execution.

WellAI is currently working with primary care and urgent care physicians and is open to working with specialists across medical disciplines and practices. The engine, as currently available, is adaptable to any solution and can enhance existing solutions (such as a pre-existing patient portal or wellness portal, IVR system, front office portal, etc.). It can interface with many EMR solutions (Cerner, Epic, Nextgen, etc.). We are open to co-innovation to integrate and enhance your current solutions (i.e. telemedicine or clinical diagnostics) with our solution.

WellAI’s Difference:

WellAI’s Digital Health Diagnostic tool presents a more compelling solution for physicians, patients and caregivers in providing a higher quality of care and patient outcomes. It offers a broader and more accurate diagnostic capability and application than online symptom checkers or clinical diagnostic tools. WellAI is essentially a full workflow technology solution for medical offices and hospitals.

With staffing shortages, the tool can drive greater efficiency while providing diagnostic accuracy with respect to patient intake, telemedicine, and optimizing patient flow. As a caregiver or patient tool, it can offset unnecessary practice visits or ER visits. As an engine, it can drive enhanced solutions for practices and healthcare organizations that previously were unimaginable. There are many more use cases that are possible.

WellAI is not a replacement for a health practitioner. It offers validation for diagnosis, eliminates time for understanding the patient’s condition, and enables a laser focus and rapid ability to begin the process of treatment with greater levels of engagement. It is a tool, like an X-Ray machine or thermometer that can support better health outcomes.